US: Man Receives Heart Transplanted From Genetically Modified Pig

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In first-of-its-kind transplant surgery, a 57-year-old Maryland man with terminal heart disease has received a genetically modified pig heart.

The patient is doing well three days after the successful surgery. David Bennett had terminal heart disease, and the pig heart was “the only currently available option,” read the University of Maryland Medical Center release. Bennett was deemed ineligible for a conventional heart transplant or an artificial heart pump after reviews of his medical records.

“It was either die or do this transplant. I want to live. I know it’s a shot in the dark, but it’s my last choice,” Bennett said before the surgery, according to the release.

“This was a breakthrough surgery and brings us one step closer to solving the organ shortage crisis. There are simply not enough donor human hearts available to meet the long list of potential recipients,” said Bartley P. Griffith, MD, who surgically transplanted the pig heart into the patient.

Earlier, the US Food and Drug Administration granted emergency authorization for the surgery on December 31.

Three genes that are responsible for the rejection of pig organs by human immune systems were removed from the donor pig, and one gene was taken out to prevent excessive pig heart tissue growth. Six human genes responsible for immune acceptance were inserted, added to the release.

Bennett’s doctors will need to monitor him for days to weeks to see whether the transplant works to provide lifesaving benefits. He will be monitored for immune system problems or other complications.

“There are simply not enough donor human hearts available to meet the long list of potential recipients,” surgeon Dr Bartley P Griffith said in a statement.

“We are proceeding cautiously, but we are also optimistic that this first-in-the-world surgery will provide an important new option for patients in the future,” he added.

In October, surgeons successfully tested the transplant of a genetically modified pig kidney into a woman in New York who was brain-dead, according to the release.

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