The Pfizer/BioNTech and Moderna coronavirus vaccines appear to protect against COVID variants B.1.617 and B.1.618 first identified in India, researchers have reported in a new pre-print paper, which has not yet been peer-reviewed.
Based on lab experiments involving cell cultures, the B.1.617 and B.1.618 variants seem to be partially resistant to the antibodies elicited by vaccination, according to the pre-print paper posted to the online server biorxiv.org on Sunday. “Thus, there is a good reason to believe that vaccinated individuals will remain protected against the B.1.617 and B.1.618 variants,” the researchers from New York University wrote in their paper. But more research is needed to determine just how effective the Pfizer/BioNTech and Moderna vaccines are against those variants in the real world.
Moreover, the World Health Organization (WHO) has classified the coronavirus variant first found in India as a “variant of global concern”.It said studies show the B.1.617 mutation spreads more easily than other variants and requires further study.
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The new research involved serum samples collected from eight people who recovered from Covid-19, six people fully vaccinated with the Pfizer/BioNTech vaccine and three people fully vaccinated with Moderna’s vaccine. The researchers analyzed in lab experiments how the serum samples neutralized lentiviruses — a type of retrovirus — equipped with the same mutations as the B.1.617 and B.1.618 coronavirus variants.
The researchers found some decreases in neutralization, but overall, antibodies from people who had been vaccinated appeared to work “well above” the serum from people who had recovered from Covid-19 caused by earlier versions of the coronavirus.
The researchers also examined how Regeneron’s monoclonal antibody cocktail therapy, called REGN-COV2, worked against the lentiviruses with B.1.617 and B.1.618 mutations — and both appeared to be “partially resistant” to the therapy.
“Our results lend confidence that current vaccines will provide protection against variants identified to date. However, the results do not preclude the possibility that variants that are more resistant to current vaccines will emerge,” the researchers wrote. “The findings highlight the importance of wide-spread adoption of vaccination which will both protect individuals from disease, decrease virus spread and slow the emergence of novel variants.”
The lab-based study was carried out by the NYU Grossman School of Medicine and NYU Langone Center. As of today, India registered 2,81,386 fresh infections were recorded in the last 24 hours, according to the Union Health Ministry’s data on Monday. The cumulative caseload stands at 2,49,65,463, including 2,11,74,076 recoveries, 35,16,997 active cases and 2,74,390 deaths.
(With ANI Inputs)