World’s tiniest thermometer created using DNA

Scientists have created the world’s tiniest thermometer that is 20,000 times smaller than a human hair, using DNA structures that can fold and unfold at specifically defined temperatures.

The advance may significantly aid our understanding of natural and human designed nanotechnologies by enabling to measure temperature at the nanoscale, researchers said.

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Over 60 years ago, researchers discovered that the DNA molecules that encode our genetic information can unfold when heated.

“In recent years, biochemists also discovered that biomolecules such as proteins or RNA (a molecule similar to DNA) are employed as nanothermometers in living organisms and report temperature variation by folding or unfolding,” said Alexis Vallee-Belisle, professor at University of Montreal in Canada.

“Inspired by those natural nanothermometers, which are typically 20,000 times smaller than a human hair, we have created various DNA structures that can fold and unfold at specifically defined temperatures,” said Vallee-Belisle.

One of the main advantages of using DNA to engineer molecular thermometers is that DNA chemistry is relatively simple and programmable.

“DNA is made from four different monomer molecules called nucleotides – nucleotide A binds weakly to nucleotide T, whereas nucleotide C binds strongly to nucleotide G,” said David Gareau, from the University of Montreal.

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“Using these simple design rules we are able to create DNA structures that fold and unfold at a specifically desired temperature,” Gareau said.

“By adding optical reporters to these DNA structures, we can therefore create 5 nm-wide thermometers that produce an easily detectable signal as a function of temperature,” said Arnaud Desrosiers, from the University of Montreal.

These nanoscale thermometers open many exciting avenues in the emerging field of nanotechnology, and may even help us to better understand molecular biology.

“There are still many unanswered questions in biology,” said Vallee-Belisle.

“For example, we know that the temperature inside the human body is maintained at 37 degrees Celsius, but we have no idea whether there is a large temperature variation at the nanoscale inside each individual cell,” she said.

Researchers are trying to determine whether nanomachines and nanomotors developed by nature over millions years of evolution also overheat when functioning at high rate.

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“In the near future, we also envision that these DNA-based nanothermometers may be implemented in electronic-based devices in order to monitor local temperature variation at the nanoscale,” said Vallee-Belisle.

The study was published in the journal Nano Letters.


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